This guide is designed to help your health center successfully collect SO/GI data, no matter where you are in the process. For those just beginning, the guide can be used from start to finish. If you have already created a system, but have encountered challenges and questions, this guide can help you address them. Even if your system is working smoothly, you will find resources and recommendations here that will help you move to the next level of data collection and analysis. This newly updated publication includes information on how to work with undocumented patients, patients who speak English as a second language or not at all, and patients who may engage in same-sex behaviors or have a gender identity that is different from their sex assigned at birth, but who do not identify as LGBTQIA+.